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Lerociclib dihydrochloride
CAS No. 2097938-59-3
Lerociclib dihydrochloride ( G1T38 dihydrochloride )
Catalog No. M23948 CAS No. 2097938-59-3
Lerociclib dihydrochloride is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3?and CDK4/CyclinD1, respectively.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLerociclib dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLerociclib dihydrochloride is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3?and CDK4/CyclinD1, respectively.?
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DescriptionLerociclib dihydrochloride is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3?and CDK4/CyclinD1, respectively.?
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SynonymsG1T38 dihydrochloride
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PathwayAngiogenesis
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TargetCDK
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RecptorCdk4/cyclin D1;cdk6/cyclin D3;CDK9/Cyclin T;CDK5/p35;Cdk5/p25;cdk2/cyclin A;CDK2/cyclinE;CDK1/cyclinB1;CDK7/Cyclin H/MAT1
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Research Area——
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Indication——
Chemical Information
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CAS Number2097938-59-3
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Formula Weight547.5
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Molecular FormulaC26H36Cl2N8O
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Purity>98% (HPLC)
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SolubilityH2O:4 mg/mL (7.31 mM; Need ultrasonic)
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SMILESCC(C)N1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C5C(=O)NCC6(N5C4=N3)CCCCC6.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bisi JE, et al. Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors. Oncotarget. 2017 Jun 27;8(26):42343-42358.
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