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Lerociclib dihydrochloride

CAS No. 2097938-59-3

Lerociclib dihydrochloride ( G1T38 dihydrochloride )

Catalog No. M23948 CAS No. 2097938-59-3

Lerociclib dihydrochloride is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3?and CDK4/CyclinD1, respectively.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lerociclib dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Lerociclib dihydrochloride is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3?and CDK4/CyclinD1, respectively.?
  • Description
    Lerociclib dihydrochloride is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3?and CDK4/CyclinD1, respectively.?
  • Synonyms
    G1T38 dihydrochloride
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    Cdk4/cyclin D1;cdk6/cyclin D3;CDK9/Cyclin T;CDK5/p35;Cdk5/p25;cdk2/cyclin A;CDK2/cyclinE;CDK1/cyclinB1;CDK7/Cyclin H/MAT1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2097938-59-3
  • Formula Weight
    547.5
  • Molecular Formula
    C26H36Cl2N8O
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:4 mg/mL (7.31 mM; Need ultrasonic)
  • SMILES
    CC(C)N1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C5C(=O)NCC6(N5C4=N3)CCCCC6.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bisi JE, et al. Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors. Oncotarget. 2017 Jun 27;8(26):42343-42358.
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